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101.
胰岛素抵抗性高血压大鼠α1肾上腺素受体亚型的改变 总被引:2,自引:0,他引:2
目的和方法:用高糖喂养复制胰岛素抵抗性高血压(insulin-resistanthypertension,IRH)大鼠模型,用放射配体结合实验和离体左心房及主动脉收缩功能实验,观察IRH大鼠α1肾上腺素受体(α1-adrenoceptor,α1-AR)及其3种亚型在心脏和主动脉的改变。结果和结论:IRH大鼠与同龄SD大鼠相比:(1)心脏α1-AR密度下降48%(P<005),而介导的正性变力效应不变。(2)心脏α1-AR3种亚型占α1-AR总数的比例和在介导心脏正性变力效应中的作用表现为α1B-AR增加,α1D-AR减少,而α1A-AR不变。(3)介导主动脉收缩的α1-AR及各亚型对激动剂的敏感性及最大收缩效应均无明显改变。 相似文献
102.
目的探讨中老年人高血压、冠心病、糖尿病胰岛素抵抗的状况及相关因素。方法按中老年高血压病、冠心病、糖尿病、高血压合并冠心病等类别分组、并设对照组,计体重指数、测血脂、血糖、胰岛素及胰岛素抗体浓度,并根据血糖、血胰岛素浓度计算胰岛素敏感性.结果胰岛素抵抗在冠心病、高血压病、高血压合并冠心病及糖尿病中依次递增.设对照组胰岛素相对敏感性为1,则上述各病分别为083、0.79、061、0.32.与之相伴随的是糖及脂质代谢紊乱及体重指数的增加。结论高血压、冠心病、糖尿病多存在胰岛素抵抗,并可能是心血管疾病的危险因子。 相似文献
103.
Treatment with combined oral contraceptives induces a rise in serum C-reactive protein in the absence of a general inflammatory response 总被引:2,自引:0,他引:2
M. VAN ROOIJEN L. O. HANSSON† J. FROSTEGÅRD‡ A. SILVEIRA§ A. HAMSTEN§ K. BREMME 《Journal of thrombosis and haemostasis》2006,4(1):77-82
BACKGROUND: The role of inflammation in the pathogenesis of cardiovascular disease is well established. C-reactive protein (CRP) is the strongest independent predictor of myocardial infarction and stroke in women. Recent studies have indicated that CRP levels are raised during use of combined oral contraceptives (COCs). OBJECTIVES: The aim of the study was to investigate the effect of COCs on serum CRP levels and to indicate the underlying mechanisms of an expected increase. METHOD: In a prospective randomized cross over-study 35 women used two different preparations of COC, one second and one third generation. Serum levels of CRP, serum amyloid A (SAA), interleukin-6 (IL-6), tumor necrosis factor alpha (TNFalpha), antibodies against oxidized LDL, insulin and insulin-like growth factor-I (IGF-I) along with insulin-like growth factor binding protein-1 (IGFBP-1) and IGFBP-3 were analyzed before and during the two treatments. E-selectin, von Willebrand factor and factor VIII concentrations in plasma were also measured. RESULTS: A rise in serum CRP was observed during both treatments; the median level increased from 0.45 mg L(-1) at baseline to 1.48 mg L(-1) with second generation and to 2.02 mg L(-1) with third generation COC. The serum levels of SAA increased slightly during treatment with the third generation COC. IL-6 and TNFalpha were unaffected by treatment. Both preparations lowered IGF-I and raised IGFBP-1 and IGFBP-3 concentrations. CONCLUSION: The raised serum CRP concentration during treatment with COCs appears to be related to a direct effect on hepatocyte CRP synthesis and does not reflect IL-6 mediated inflammation, endothelial activation or induction of insulin resistance. 相似文献
104.
Toshikazu Tanaka Peter C Amadio Chunfeng Zhao Mark E Zobitz Kai-Nan An 《Journal of orthopaedic research》2006,24(4):757-762
While attrition from sharp bony surfaces is the most common cause of extensor digiti minimi (EDM) tendon rupture, the etiology of other cases of spontaneous EDM tendon rupture is still unknown. Friction within the compartment may play a role, especially with ulna dislocation. The purpose of this study was to compare gliding resistance of the EDM tendon with that of a tendon which rarely ruptures spontaneously, the extensor digitorum communis of the middle finger (EDC III) tendon, under various wrist and ulna head positions. Eight fresh frozen cadavers were used. Gliding resistance between the tendon and its sheath in each compartment was measured in five different wrist positions and three different ulna head positions. Gliding resistance of the EDM tendon (0.13 +/- 0.03 N) was significantly greater than the EDC III tendon (0.09 +/- 0.03 N) (p < 0.05). For the EDM tendon, the gliding resistance in ulnar deviation or pronation was higher than the gliding resistance in neutral, radial deviation, or supination (p < 0.05), and the gliding resistance with ulnar lengthening (over 6 mm) or dorsal ulnar dislocation (over 9 mm) was higher than in neutral ulnar head positioning. For the EDC III tendon, the gliding resistance in ulnar deviation was significantly higher than the gliding resistance in neutral, radial deviation, or supination, or dorsal dislocation with ulnar lengthening (p < 0.05). Wrist ulnar deviation, ulnar dorsal dislocation (over 9 mm), and ulnar lengthening (over 6 mm) increased the gliding resistance of the EDM tendon. In patients at risk for EDM rupture, such as those with rheumatoid arthritis or distal radioulnar joint osteoarthritis, avoiding such positions may be advantageous. 相似文献
105.
目的:观察代谢综合征(MS)患者血管内皮损伤标志物血管性假性血友病因子抗原(vWF:Ag)、凝血酶调节蛋白(TM)及超敏C反应蛋白(Hs-CRP)的水平变化及其与胰岛素抵抗的关系。方法:测定67例MS患者(其中合并冠心病31例)及35例健康对照组TM、vWF:Ag、Hs-CRP、空腹胰岛素(Fins)水平,计算胰岛素抵抗指数(IR)。结果:单纯MS组(B组)TM、vWF:Ag、Hs-CRP水平明显高于对照组(A组),P<0.05;MS合并冠心病组(C组)TM、vWF:Ag、Hs-CRP水平均高于A组和B组,差异有显著性统计学意义(P<0.05)。单因素直线相关分析表明TM、vWF:Ag、Hs-CRP与IR显著正相关(r分别为0.32、0.36、0.38)。结论:MS患者血管内皮损伤标志物、CRP水平升高,且与IR抵抗有关。 相似文献
106.
人体下颌牙槽骨皮质骨是各向异性复合生物材料,组织结构上类似于胶原羟磷灰石纤维增强的单向纤维增强复合材料。本文应用电测法测试了不同状态人体下颌牙槽骨皮质骨在平面应力状态下的各向异性弹性常数。 相似文献
107.
Taking as its point of departure the medicalization thesis and its limitations, this paper provides a critical discussion of certain more recent theoretical perspectives on life in contemporary society, and their relevance for understanding the relationship between modern medicine and the lay populace. In particular, attention is paid to the contours and existential parameters of life in ‘late’ modernity in terms of the following four key themes: (i) modernity as a ‘reflexive’ social order; (ii) ‘risk’ and the dialectic of scientific and social rationality; (iii) the ‘mediation’ of contemporary experience; and (iv) lay ‘re-skilling’ and the ‘life political’ agenda. On the basis of this, it is argued that far from being simply passive and dependent, a ‘critical distance’ is beginning to emerge between modern medicine and the lay populace; a situation which resonates with broader social trends and currents within society at large. 相似文献
108.
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110.
进一步研究了抗三尖杉酯碱的HL-60细胞(HR20)抗细胞凋亡的机制及该抗性和抗药性的关系。结果表明,环孢菌素A(CsA)20,10μg·ml ̄(-1)诱导HL-60细胞发生凋亡,而阻断HR20细胞于G_1期,就不能诱导细胞发生凋亡。低浓度的CsA明显增加柔红霉素在HR20细胞内的积聚,其逆转抗药性作用与阻断细胞周期运行无关。CsA10μg·ml ̄(-1)处理HR20细胞,可引起50kDa的蛋白质高度磷酸化。结果提示:环孢菌素A阻断抗三尖杉酯碱的HL-60细胞于G_1期,而诱导敏感的HL-60细胞发生凋亡,其阻断作用与抗药性无关 相似文献